Probing the Druggablility on the Interface of the Protein–Protein Interaction and Its Allosteric Regulation Mechanism on the Drug Screening for the CXCR4 Homodimer

Modulating protein–protein interactions (PPIs) with small drug-like molecules targeting it exhibits great promise in modern drug discovery. G protein-coupled receptors (GPCRs) are the largest family of targeted proteins and could form dimers in living biological cells through PPIs. However, compared...

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Detalles Bibliográficos
Autores principales: Shen, Liting, Yuan, Yuan, Guo, Yanzhi, Li, Menglong, Li, Chuan, Pu, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855241/
https://www.ncbi.nlm.nih.gov/pubmed/31787895
http://dx.doi.org/10.3389/fphar.2019.01310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855241/
https://www.ncbi.nlm.nih.gov/pubmed/31787895
http://dx.doi.org/10.3389/fphar.2019.01310

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