Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous system. To guide their application across disease models, and to inspire the development of translational gene therapy vectors for targeting neurological diseases in humans, we s...

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Detalles Bibliográficos
Autores principales: Huang, Qin, Chan, Ken Y., Tobey, Isabelle G., Chan, Yujia Alina, Poterba, Tim, Boutros, Christine L., Balazs, Alejandro B., Daneman, Richard, Bloom, Jonathan M., Seed, Cotton, Deverman, Benjamin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855452/
https://www.ncbi.nlm.nih.gov/pubmed/31725765
http://dx.doi.org/10.1371/journal.pone.0225206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855452/
https://www.ncbi.nlm.nih.gov/pubmed/31725765
http://dx.doi.org/10.1371/journal.pone.0225206

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