IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

IFI16, an innate immune DNA sensor, recognizes the nuclear episomal herpes viral genomes and induces the inflammasome and interferon-β responses. IFI16 also regulates cellular transcription and act as a DNA virus restriction factor. IFI16 knockdown disrupted the latency of Kaposi’s sarcoma associate...

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Detalles Bibliográficos
Autores principales: Roy, Arunava, Ghosh, Anandita, Kumar, Binod, Chandran, Bala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855800/
https://www.ncbi.nlm.nih.gov/pubmed/31682228
http://dx.doi.org/10.7554/eLife.49500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855800/
https://www.ncbi.nlm.nih.gov/pubmed/31682228
http://dx.doi.org/10.7554/eLife.49500

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