Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

Unesterified cholesterol accumulation in the late endosomal/lysosomal (LE/LY) compartment is the cellular hallmark of Niemann-Pick C (NPC) disease, caused by defects in the genes encoding NPC1 or NPC2. We previously reported the dramatic stimulation of NPC2 cholesterol transport rates to and from mo...

Descripción completa

Detalles Bibliográficos
Autores principales: McCauliff, Leslie A, Langan, Annette, Li, Ran, Ilnytska, Olga, Bose, Debosreeta, Waghalter, Miriam, Lai, Kimberly, Kahn, Peter C, Storch, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855803/
https://www.ncbi.nlm.nih.gov/pubmed/31580258
http://dx.doi.org/10.7554/eLife.50832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855803/
https://www.ncbi.nlm.nih.gov/pubmed/31580258
http://dx.doi.org/10.7554/eLife.50832

Ejemplares similares