Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

Intracellular trafficking depends on the function of Rab GTPases, whose activation is regulated by guanine exchange factors (GEFs). The Rab5 GEF, Rabex5, was previously proposed to be auto-inhibited by its C-terminus. Here, we studied full-length Rabex5 and Rabaptin5 proteins as well as domain delet...

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Detalles Bibliográficos
Autores principales: Lauer, Janelle, Segeletz, Sandra, Cezanne, Alice, Guaitoli, Giambattista, Raimondi, Francesco, Gentzel, Marc, Alva, Vikram, Habeck, Michael, Kalaidzidis, Yannis, Ueffing, Marius, Lupas, Andrei N, Gloeckner, Christian Johannes, Zerial, Marino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855807/
https://www.ncbi.nlm.nih.gov/pubmed/31718772
http://dx.doi.org/10.7554/eLife.46302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855807/
https://www.ncbi.nlm.nih.gov/pubmed/31718772
http://dx.doi.org/10.7554/eLife.46302

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