Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

Pentameric ligand-gated ion channels (pLGICs) are essential determinants of synaptic transmission, and are modulated by specific lipids including anionic phospholipids. The exact modulatory effect of anionic phospholipids in pLGICs and the mechanism of this effect are not well understood. Using nati...

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Detalles Bibliográficos
Autores principales: Tong, Ailing, Petroff, John T, Hsu, Fong-Fu, Schmidpeter, Philipp AM, Nimigean, Crina M, Sharp, Liam, Brannigan, Grace, Cheng, Wayland WL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855808/
https://www.ncbi.nlm.nih.gov/pubmed/31724949
http://dx.doi.org/10.7554/eLife.50766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855808/
https://www.ncbi.nlm.nih.gov/pubmed/31724949
http://dx.doi.org/10.7554/eLife.50766

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