Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease

The accumulation of amyloid-β protein (Aβ) in brain is linked to the early pathogenesis of Alzheimer’s disease (AD). We previously reported that neuron-derived exosomes promote Aβ clearance in the brains of amyloid precursor protein transgenic mice and that exosome production is modulated by ceramid...

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Detalles Bibliográficos
Autores principales: Yuyama, Kohei, Takahashi, Kaori, Usuki, Seigo, Mikami, Daisuke, Sun, Hui, Hanamatsu, Hisatoshi, Furukawa, Junichi, Mukai, Katsuyuki, Igarashi, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856149/
https://www.ncbi.nlm.nih.gov/pubmed/31727994
http://dx.doi.org/10.1038/s41598-019-53394-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856149/
https://www.ncbi.nlm.nih.gov/pubmed/31727994
http://dx.doi.org/10.1038/s41598-019-53394-w

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