Discovery of a potent small molecule inhibiting Huntington’s disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein

CAG repeats RNA causes various fatal neurodegenerative diseases exemplified by Huntington’s disease (HD) and several spinocerebellar ataxias (SCAs). Although there are differences in the pathogenic mechanisms, these diseases share the common cause, i.e., expansion of CAG repeats. The shared cause of...

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Detalles Bibliográficos
Autores principales: Khan, Eshan, Mishra, Subodh Kumar, Mishra, Ribhav, Mishra, Amit, Kumar, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856162/
https://www.ncbi.nlm.nih.gov/pubmed/31728006
http://dx.doi.org/10.1038/s41598-019-53410-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856162/
https://www.ncbi.nlm.nih.gov/pubmed/31728006
http://dx.doi.org/10.1038/s41598-019-53410-z

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