Piezo1 channel activation mimics high glucose as a stimulator of insulin release

Glucose and hypotonicity induced cell swelling stimulate insulin release from pancreatic β-cells but the mechanisms are poorly understood. Recently, Piezo1 was identified as a mechanically-activated nonselective Ca(2+) permeable cationic channel in a range of mammalian cells. As cell swelling induce...

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Detalles Bibliográficos
Autores principales: Deivasikamani, Vijayalakshmi, Dhayalan, Savitha, Abudushalamu, Yilizila, Mughal, Romana, Visnagri, Asjad, Cuthbertson, Kevin, Scragg, Jason L., Munsey, Tim S., Viswambharan, Hema, Muraki, Katsuhiko, Foster, Richard, Sivaprasadarao, Asipu, Kearney, Mark T., Beech, David J., Sukumar, Piruthivi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856185/
https://www.ncbi.nlm.nih.gov/pubmed/31727906
http://dx.doi.org/10.1038/s41598-019-51518-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856185/
https://www.ncbi.nlm.nih.gov/pubmed/31727906
http://dx.doi.org/10.1038/s41598-019-51518-w

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