Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation

Gain-of-function mutations in the chloride channel ClC-2 were recently described as a cause of familial hyperaldosteronism type II (FH-II). Here, we report the generation of a mouse model carrying a missense mutation homologous to the most common FH-II-associated CLCN2 mutation. In these Clcn2(R180Q...

Descripción completa

Detalles Bibliográficos
Autores principales: Schewe, Julia, Seidel, Eric, Forslund, Sofia, Marko, Lajos, Peters, Jörg, Muller, Dominik N., Fahlke, Christoph, Stölting, Gabriel, Scholl, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856192/
https://www.ncbi.nlm.nih.gov/pubmed/31727896
http://dx.doi.org/10.1038/s41467-019-13033-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856192/
https://www.ncbi.nlm.nih.gov/pubmed/31727896
http://dx.doi.org/10.1038/s41467-019-13033-4

Ejemplares similares