Fundamental Roles of Chromatin Loop Extrusion in Antibody Class Switching

Antibody class switch recombination (CSR) in B lymphocytes replaces immunoglobulin heavy chain locus (Igh) Cμconstant region exons (C(H)s) with one of 6 C(H)s lying 100-200kb downstream(1). Each C(H) is flanked upstream by an I-promoter and long repetitive switch (S) region(1). Cytokines/activators...

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Detalles Bibliográficos
Autores principales: Zhang, Xuefei, Zhang, Yu, Ba, Zhaoqing, Kyritsis, Nia, Casellas, Rafael, Alt, Frederick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856444/
https://www.ncbi.nlm.nih.gov/pubmed/31666703
http://dx.doi.org/10.1038/s41586-019-1723-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856444/
https://www.ncbi.nlm.nih.gov/pubmed/31666703
http://dx.doi.org/10.1038/s41586-019-1723-0

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