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Structures of neurexophilin–neurexin complexes reveal a regulatory mechanism of alternative splicing

Neurexins are presynaptic, cell‐adhesion molecules that specify the functional properties of synapses via interactions with trans‐synaptic ligands. Neurexins are extensively alternatively spliced at six canonical sites that regulate multifarious ligand interactions, but the structural mechanisms und...

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Detalles Bibliográficos
Autores principales: Wilson, Steven C, White, K Ian, Zhou, Qiangjun, Pfuetzner, Richard A, Choi, Ucheor B, Südhof, Thomas C, Brunger, Axel T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856630/
https://www.ncbi.nlm.nih.gov/pubmed/31566781
http://dx.doi.org/10.15252/embj.2019101603