DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency

The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target loci. Here, we demonstrate that 3D genome organization...

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Detalles Bibliográficos
Autores principales: McLaughlin, Katy, Flyamer, Ilya M., Thomson, John P., Mjoseng, Heidi K., Shukla, Ruchi, Williamson, Iain, Grimes, Graeme R., Illingworth, Robert S., Adams, Ian R., Pennings, Sari, Meehan, Richard R., Bickmore, Wendy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856714/
https://www.ncbi.nlm.nih.gov/pubmed/31722211
http://dx.doi.org/10.1016/j.celrep.2019.10.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856714/
https://www.ncbi.nlm.nih.gov/pubmed/31722211
http://dx.doi.org/10.1016/j.celrep.2019.10.031

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