Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

Rett Syndrome (RTT) is an X-linked neurodevelopmental disorder associated with respiratory abnormalities and, in up to ~40% of patients, with prolongation of the cardiac QT(c) interval. QT(c) prolongation calls for cautious use of drugs with a propensity to inhibit hERG channels. The STARS trial has...

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Detalles Bibliográficos
Autores principales: Cheng, Hongwei, Du, Chunyun, Zhang, Yihong, James, Andrew F., Dempsey, Christopher E., Abdala, Ana P., Hancox, Jules C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856717/
https://www.ncbi.nlm.nih.gov/pubmed/31362019
http://dx.doi.org/10.1016/j.yjmcc.2019.07.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856717/
https://www.ncbi.nlm.nih.gov/pubmed/31362019
http://dx.doi.org/10.1016/j.yjmcc.2019.07.012

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