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Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome
Rett Syndrome (RTT) is an X-linked neurodevelopmental disorder associated with respiratory abnormalities and, in up to ~40% of patients, with prolongation of the cardiac QT(c) interval. QT(c) prolongation calls for cautious use of drugs with a propensity to inhibit hERG channels. The STARS trial has...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856717/ https://www.ncbi.nlm.nih.gov/pubmed/31362019 http://dx.doi.org/10.1016/j.yjmcc.2019.07.012 |