Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

Parkinson’s disease (PD) is characterized by the death of dopamine neurons in the substantia nigra pars compacta (SNc) and accumulation of α-synuclein. Impaired autophagy has been implicated and activation of autophagy proposed as a treatment strategy. We generate a human α-synuclein-expressing mous...

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Príomhchruthaitheoirí: Hunn, Benjamin H.M., Vingill, Siv, Threlfell, Sarah, Alegre-Abarrategui, Javier, Magdelyns, Morgane, Deltheil, Thierry, Bengoa-Vergniory, Nora, Oliver, Peter L., Cioroch, Milena, Doig, Natalie M., Bannerman, David M., Cragg, Stephanie J., Wade-Martins, Richard
Formáid: Online Alt Téacs
Teanga:English
Foilsithe / Cruthaithe: Cell Press 2019
Ábhair:
Article
Rochtain ar líne:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856726/
https://www.ncbi.nlm.nih.gov/pubmed/31644913
http://dx.doi.org/10.1016/j.celrep.2019.09.029

Ar líne

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856726/
https://www.ncbi.nlm.nih.gov/pubmed/31644913
http://dx.doi.org/10.1016/j.celrep.2019.09.029

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