Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

Parkinson’s disease (PD) is characterized by the death of dopamine neurons in the substantia nigra pars compacta (SNc) and accumulation of α-synuclein. Impaired autophagy has been implicated and activation of autophagy proposed as a treatment strategy. We generate a human α-synuclein-expressing mous...

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Detalles Bibliográficos
Autores principales: Hunn, Benjamin H.M., Vingill, Siv, Threlfell, Sarah, Alegre-Abarrategui, Javier, Magdelyns, Morgane, Deltheil, Thierry, Bengoa-Vergniory, Nora, Oliver, Peter L., Cioroch, Milena, Doig, Natalie M., Bannerman, David M., Cragg, Stephanie J., Wade-Martins, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856726/
https://www.ncbi.nlm.nih.gov/pubmed/31644913
http://dx.doi.org/10.1016/j.celrep.2019.09.029

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