Conditional knockout of TGF-βRII /Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation

Rationale: TGF-β/Smad signaling is the central mediator for renal fibrosis, however, its functional role in acute kidney injury (AKI) is not fully understood. We previously showed Smad2 protects against renal fibrosis by limiting Smad3 signaling, but details on its role in acute phase are unclear. R...

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Detalles Bibliográficos
Autores principales: Yang, Qin, Ren, Gui-ling, Wei, Biao, Jin, Juan, Huang, Xiao Ru, Shao, Wei, Li, Jun, Meng, Xiao-ming, Lan, Hui Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857044/
https://www.ncbi.nlm.nih.gov/pubmed/31754396
http://dx.doi.org/10.7150/thno.35686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857044/
https://www.ncbi.nlm.nih.gov/pubmed/31754396
http://dx.doi.org/10.7150/thno.35686

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