Nanotopography-based lymphatic delivery for improved anti-tumor responses to checkpoint blockade immunotherapy

Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against “self” antigens (Ags). In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust activation of T-cells a...

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Detalles Bibliográficos
Autores principales: Kwon, Sunkuk, Velasquez, Fred Christian, Rasmussen, John C., Greives, Matthew R., Turner, Kelly D., Morrow, John R., Hwu, Wen-Jen, Ross, Russell F., Zhang, Songlin, Sevick-Muraca, Eva M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857054/
https://www.ncbi.nlm.nih.gov/pubmed/31754400
http://dx.doi.org/10.7150/thno.35280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857054/
https://www.ncbi.nlm.nih.gov/pubmed/31754400
http://dx.doi.org/10.7150/thno.35280

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