Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies

BACKGROUND: A large number of analysis strategies are available for DNA methylation (DNAm) array and RNA-seq datasets, but it is unclear which strategies are best to use. We compare commonly used strategies and report how they influence results in large cohort studies. RESULTS: We tested the associa...

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Detalles Bibliográficos
Autores principales: van Rooij, Jeroen, Mandaviya, Pooja R., Claringbould, Annique, Felix, Janine F., van Dongen, Jenny, Jansen, Rick, Franke, Lude, ’t Hoen, Peter A. C., Heijmans, Bas, van Meurs, Joyce B. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857161/
https://www.ncbi.nlm.nih.gov/pubmed/31727104
http://dx.doi.org/10.1186/s13059-019-1878-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857161/
https://www.ncbi.nlm.nih.gov/pubmed/31727104
http://dx.doi.org/10.1186/s13059-019-1878-x

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