Cargando…

Application of CRISPR genetic screens to investigate neurological diseases

The adoption of CRISPR-Cas9 technology for functional genetic screens has been a transformative advance. Due to its modular nature, this technology can be customized to address a myriad of questions. To date, pooled, genome-scale studies have uncovered genes responsible for survival, proliferation,...

Descripción completa

Detalles Bibliográficos
Autores principales:	So, Raphaella W. L., Chung, Sai Wai, Lau, Heather H. C., Watts, Jeremy J., Gaudette, Erin, Al-Azzawi, Zaid A. M., Bishay, Jossana, Lin, Lilian Tsai-Wei, Joung, Julia, Wang, Xinzhu, Schmitt-Ulms, Gerold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857349/ https://www.ncbi.nlm.nih.gov/pubmed/31727120 http://dx.doi.org/10.1186/s13024-019-0343-3

Ejemplares similares

The aminoglycoside G418 hinders de novo prion infection in cultured cells
por: Arshad, Hamza, et al.
Publicado: (2021)

Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins
por: Wang, Xinzhu, et al.
Publicado: (2019)

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
por: Ruiz-Riquelme, Alejandro, et al.
Publicado: (2018)

CRISPR-Cas9-Based Knockout of the Prion Protein and Its Effect on the Proteome
por: Mehrabian, Mohadeseh, et al.
Publicado: (2014)

Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters
por: Schmitt-Ulms, Gerold, et al.
Publicado: (2009)

Potential Role of Venular Amyloid in Alzheimer’s Disease Pathogenesis
por: Morrone, Christopher D., et al.
Publicado: (2020)

The cellular prion protein interacts with and promotes the activity of Na,K-ATPases
por: Williams, Declan, et al.
Publicado: (2021)

An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition
por: Mehrabian, Mohadeseh, et al.
Publicado: (2014)

NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being?
por: Mehrabian, Mohadeseh, et al.
Publicado: (2016)

The Evolutionary unZIPping of a Dimerization Motif—A Comparison of ZIP and PrP Architectures
por: Hu, Jian, et al.
Publicado: (2017)

The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease
por: Lau, Heather H. C., et al.
Publicado: (2023)

Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein
por: Eid, Shehab, et al.
Publicado: (2022)

Somatostatin in Alzheimer's disease: A new Role for an Old Player
por: Solarski, Michael, et al.
Publicado: (2018)

Cardiac glycoside-mediated turnover of Na, K-ATPases as a rational approach to reducing cell surface levels of the cellular prion protein
por: Mehrabian, Mohadeseh, et al.
Publicado: (2022)

Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to Fyn
por: Wang, Hansen, et al.
Publicado: (2013)

Aggregation of Aβ(40/42) chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations
por: Wu, Min, et al.
Publicado: (2021)

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice
por: Ruiz-Riquelme, Alejandro, et al.
Publicado: (2021)

Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer’s disease
por: Morrone, Christopher Daniel, et al.
Publicado: (2022)

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition
por: Brethour, Dylan, et al.
Publicado: (2017)

The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling
por: Ghodrati, Farinaz, et al.
Publicado: (2018)

The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis
por: Mehrabian, Mohadeseh, et al.
Publicado: (2015)

The human brain somatostatin interactome: SST binds selectively to P-type family ATPases
por: Solarski, Michael, et al.
Publicado: (2019)

Evidence for Retrogene Origins of the Prion Gene Family
por: Ehsani, Sepehr, et al.
Publicado: (2011)

Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue
por: Mehrabian, Mohadeseh, et al.
Publicado: (2016)

α-Synuclein Strains Target Distinct Brain Regions and Cell Types
por: Lau, Angus, et al.
Publicado: (2019)

Interactome Analyses Identify Ties of PrP(C) and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones
por: Watts, Joel C., et al.
Publicado: (2009)

Correction: Interactome Analyses Identify Ties of PrP(C) and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones
por: Watts, Joel C., et al.
Publicado: (2009)

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration
por: Taylor, Kathryn M., et al.
Publicado: (2016)

Drug Repositioning for Alzheimer’s Disease Based on Systematic ‘omics’ Data Mining
por: Zhang, Ming, et al.
Publicado: (2016)

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APP(NL-F) mouse model of Alzheimer disease
por: Wang, Hansen, et al.
Publicado: (2017)

PrionHome: A Database of Prions and Other Sequences Relevant to Prion Phenomena
por: Harbi, Djamel, et al.
Publicado: (2012)

The MEF2A transcription factor interactome in cardiomyocytes
por: Moustafa, Amira, et al.
Publicado: (2023)

Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
por: Wang, Hansen, et al.
Publicado: (2017)

Somatostatin slows Aβ plaque deposition in aged APP(NL-F/NL-F) mice by blocking Aβ aggregation
por: Williams, Declan, et al.
Publicado: (2023)

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage
por: Pardossi-Piquard, Raphaëlle, et al.
Publicado: (2009)

Structural biology of presenilin 1 complexes
por: Li, Yi, et al.
Publicado: (2014)

Proteome-wide identification of mycobacterial pupylation targets
por: Poulsen, Christian, et al.
Publicado: (2010)

Recent Scientific Breakthroughs Applying CRISPR Gene Editing in Neurological Disorders
por: Assadi-Khansari, Mitra, et al.
Publicado: (2021)

An endogenous PI3K interactome promoting astrocyte-mediated neuroprotection identifies a novel association with RNA-binding protein ZC3H14
por: Alqawlaq, Samih, et al.
Publicado: (2020)

GBA1 and The Immune System: A Potential Role in Parkinson’s Disease?
por: Al-Azzawi, Zaid A.M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_444806e2ee9ed0s9et13jckufi