Germline DNA Retention in Murine and Human Rearranged T Cell Receptor Gene Coding Joints: Alternative Recombination Signal Sequences and V(D)J Recombinase Errors

The genes coding for the antigenic T cell receptor (TR) subunits are assembled in thymocytes from discrete V, D, and J genes by a site-specific recombination process. A tight control of this activity is required to prevent potentially detrimental recombination events. V, D, and J genes are flanked b...

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Detalles Bibliográficos
Autores principales: Mika, Justyna, Kabacik, Sylwia, Badie, Christophe, Polanska, Joanna, Candéias, Serge M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857471/
https://www.ncbi.nlm.nih.gov/pubmed/31781122
http://dx.doi.org/10.3389/fimmu.2019.02637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857471/
https://www.ncbi.nlm.nih.gov/pubmed/31781122
http://dx.doi.org/10.3389/fimmu.2019.02637

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