Nanosome-Mediated Delivery Of Protein Kinase D Inhibitor Protects Chondrocytes From Interleukin-1β-Induced Stress And Apoptotic Death

BACKGROUND: Inflammatory stress caused by protein kinase D (PKD) plays a critical role in damaging chondrocytes and extracellular matrix (ECM) during osteoarthritis (OA). The PKD inhibitor (PKDi) (CRT0066101) has been used to overcome inflammation in different cell types. However, the efficacy of a...

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Detalles Bibliográficos
Autores principales: Cho, Hongsik, Bhatti, Fazal-Ur-Rehman, Hasty, Karen A, Yi, Ae-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857658/
https://www.ncbi.nlm.nih.gov/pubmed/31806974
http://dx.doi.org/10.2147/IJN.S218901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857658/
https://www.ncbi.nlm.nih.gov/pubmed/31806974
http://dx.doi.org/10.2147/IJN.S218901

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