Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function

Allosteric changes imposed by post-translational modifications regulate and differentiate the functions of proteins with intrinsic disorder regions. HDM2 is a hub protein with a large interactome and with different cellular functions. It is best known for its regulation of the p53 tumour suppressor....

Descripción completa

Detalles Bibliográficos
Autores principales: Uhrik, Lukas, Wang, Lixiao, Haronikova, Lucia, Medina-Medina, Ixaura, Rebolloso-Gomez, Yolanda, Chen, Sa, Vojtesek, Borivoj, Fahraeus, Robin, Hernychova, Lenka, Olivares-Illana, Vanesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857739/
https://www.ncbi.nlm.nih.gov/pubmed/31652301
http://dx.doi.org/10.1042/BCJ20190687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857739/
https://www.ncbi.nlm.nih.gov/pubmed/31652301
http://dx.doi.org/10.1042/BCJ20190687

Ejemplares similares