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Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function

Allosteric changes imposed by post-translational modifications regulate and differentiate the functions of proteins with intrinsic disorder regions. HDM2 is a hub protein with a large interactome and with different cellular functions. It is best known for its regulation of the p53 tumour suppressor....

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Detalles Bibliográficos
Autores principales:	Uhrik, Lukas, Wang, Lixiao, Haronikova, Lucia, Medina-Medina, Ixaura, Rebolloso-Gomez, Yolanda, Chen, Sa, Vojtesek, Borivoj, Fahraeus, Robin, Hernychova, Lenka, Olivares-Illana, Vanesa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857739/ https://www.ncbi.nlm.nih.gov/pubmed/31652301 http://dx.doi.org/10.1042/BCJ20190687

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