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Binding Immunoglobulin Protein (BIP) Inhibits TNF‐α–Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model

OBJECTIVE: The association between inflammation and dysregulated bone remodeling is apparent in rheumatoid arthritis and is recapitulated in the human tumor necrosis factor transgenic (hTNFtg) mouse model. We investigated whether extracellular binding immunoglobulin protein (BiP) would protect the h...

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Detalles Bibliográficos
Autores principales: Zaiss, Mario M., Hall, Christopher, McGowan, Neil W. A., Babb, Rebecca, Devlia, Vikesh, Lucas, Sébastien, Meghji, Sajeda, Henderson, Brian, Bozec, Aline, Schett, Georg, David, Jean‐Pierre, Panayi, Gabriel S., Grigoriadis, Agamemnon E., Corrigall, Valerie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857990/
https://www.ncbi.nlm.nih.gov/pubmed/31777818
http://dx.doi.org/10.1002/acr2.11060