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Thermosensitive PBP2a requires extracellular folding factors PrsA and HtrA1 for Staphylococcus aureus MRSA β-lactam resistance

Staphylococcus aureus is a major human pathogen and represents a clinical challenge because of widespread antibiotic resistance. Methicillin resistant Staphylococcus aureus (MRSA) is particularly problematic and originates by the horizontal acquisition of mecA encoding PBP2a, an extracellular membra...

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Detalles Bibliográficos
Autores principales: Roch, Mélanie, Lelong, Emmanuelle, Panasenko, Olesya O., Sierra, Roberto, Renzoni, Adriana, Kelley, William L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858329/
https://www.ncbi.nlm.nih.gov/pubmed/31754647
http://dx.doi.org/10.1038/s42003-019-0667-0