High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na(+) channel complex

Multiple voltage-gated Na(+) (Nav) channelopathies can be ascribed to subtle changes in the Nav macromolecular complex. Fibroblast growth factor 14 (FGF14) is a functionally relevant component of the Nav1.6 channel complex, a causative link to spinocerebellar ataxia 27 (SCA27) and an emerging risk f...

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Detalles Bibliográficos
Autores principales: Wadsworth, Paul A., Folorunso, Oluwarotimi, Nguyen, Nghi, Singh, Aditya K., D’Amico, Daniela, Powell, Reid T., Brunell, David, Allen, John, Stephan, Clifford, Laezza, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858373/
https://www.ncbi.nlm.nih.gov/pubmed/31729429
http://dx.doi.org/10.1038/s41598-019-53110-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858373/
https://www.ncbi.nlm.nih.gov/pubmed/31729429
http://dx.doi.org/10.1038/s41598-019-53110-8

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