Cargando…

High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na(+) channel complex

Multiple voltage-gated Na(+) (Nav) channelopathies can be ascribed to subtle changes in the Nav macromolecular complex. Fibroblast growth factor 14 (FGF14) is a functionally relevant component of the Nav1.6 channel complex, a causative link to spinocerebellar ataxia 27 (SCA27) and an emerging risk f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wadsworth, Paul A., Folorunso, Oluwarotimi, Nguyen, Nghi, Singh, Aditya K., D’Amico, Daniela, Powell, Reid T., Brunell, David, Allen, John, Stephan, Clifford, Laezza, Fernanda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858373/ https://www.ncbi.nlm.nih.gov/pubmed/31729429 http://dx.doi.org/10.1038/s41598-019-53110-8

Ejemplares similares

Use of BRCA1 protein:protein interactions to classify cancer risk
por: Morris, JR, et al.
Publicado: (2008)

Applying bimolecular fluorescence complementation to screen and purify aquaporin protein:protein complexes
por: Sjöhamn, Jennie, et al.
Publicado: (2016)

The Cell Fate Determinant Musashi Is Controlled Through Dynamic Protein:Protein Interactions
por: Bronson, Katherine, et al.
Publicado: (2021)

Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na(+) Channel 1.6 Enables Isoform-Selective Modulation
por: Dvorak, Nolan M., et al.
Publicado: (2021)

Voltage-Gated Na(+) Channels in Alzheimer’s Disease: Physiological Roles and Therapeutic Potential
por: Baumgartner, Timothy J., et al.
Publicado: (2023)

Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na(+) Channel 1.2 Macromolecular Complex
por: Dvorak, Nolan M., et al.
Publicado: (2021)

Bayesian Analysis of MicroScale Thermophoresis Data to Quantify Affinity of Protein:Protein Interactions with Human Survivin
por: Garcia-Bonete, Maria-Jose, et al.
Publicado: (2017)

Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics
por: Dvorak, Nolan M., et al.
Publicado: (2020)

Differential Modulation of the Voltage-Gated Na(+) Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14
por: Singh, Aditya K., et al.
Publicado: (2021)

STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition
por: Bonham, Andrew J., et al.
Publicado: (2013)

Identifying and overcoming the sampling challenges in relative binding free energy calculations of a model protein:protein complex
por: Zhang, Ivy, et al.
Publicado: (2023)

Characterization in Potent Modulation on Voltage-Gated Na(+) Current Exerted by Deltamethrin, a Pyrethroid Insecticide
por: Lin, Mao-Hsun, et al.
Publicado: (2022)

Oncomorphic TP53 Mutations in Gynecologic Cancers Lose the Normal Protein:Protein Interactions with the microRNA Microprocessing Complex
por: Brachova, Pavla, et al.
Publicado: (2014)

Protein:Protein interactions in the cytoplasmic membrane apparently influencing sugar transport and phosphorylation activities of the e. coli phosphotransferase system
por: Aboulwafa, Mohammad, et al.
Publicado: (2019)

Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling
por: Adams, Ralph, et al.
Publicado: (2017)

Voltage-dependent gating of veratridine-modified Na channels
Publicado: (1986)

Differential Sialylation Modulates Voltage-gated Na(+) Channel Gating throughout the Developing Myocardium
por: Stocker, Patrick J., et al.
Publicado: (2006)

The Position of the Fast-Inactivation Gate during Lidocaine Block of Voltage-gated Na(+) Channels
por: Vedantham, Vasanth, et al.
Publicado: (1999)

Calmodulin and Ca(2+) control of voltage gated Na(+) channels
por: Gabelli, Sandra B, et al.
Publicado: (2015)

Voltage-Gated Sodium Channel Na(V)1.7 Inhibitors with Potent Anticancer Activities in Medullary Thyroid Cancer Cells
por: Pukkanasut, Piyasuda, et al.
Publicado: (2023)

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na(V)1.9, Na(V)1.7 and Na(V)1.1
por: Touska, Filip, et al.
Publicado: (2017)

Slow Inactivation Does Not Affect Movement of the Fast Inactivation Gate in Voltage-gated Na(+) Channels
por: Vedantham, Vasanth, et al.
Publicado: (1998)

Lysine and the Na(+)/K(+) Selectivity in Mammalian Voltage-Gated Sodium Channels
por: Li, Yang, et al.
Publicado: (2016)

Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
por: Rhana, P., et al.
Publicado: (2017)

Voltage-gated Na(+) currents in human dorsal root ganglion neurons
por: Zhang, Xiulin, et al.
Publicado: (2017)

Voltage-Gated K(+)/Na(+) Channels and Scorpion Venom Toxins in Cancer
por: Díaz-García, Alexis, et al.
Publicado: (2020)

A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na(+) Channels
por: Liu, Yichen, et al.
Publicado: (2023)

A mechanistic reinterpretation of fast inactivation in voltage-gated Na(+) channels
por: Liu, Yichen, et al.
Publicado: (2023)

Structure and electromechanical coupling of a voltage-gated Na(+)/H(+) exchanger
por: Yeo, Hyunku, et al.
Publicado: (2023)

A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na(+) Channels
por: Liu, Yichen, et al.
Publicado: (2023)

Gating of the Bacterial Sodium Channel, NaChBac: Voltage-dependent Charge Movement and Gating Currents
por: Kuzmenkin, Alexey, et al.
Publicado: (2004)

Mechanism of μ-Conotoxin PIIIA Binding to the Voltage-Gated Na(+) Channel Na(V)1.4
por: Chen, Rong, et al.
Publicado: (2014)

Regulatory Role of Voltage-Gated Na(+) Channel β Subunits in Sensory Neurons
por: Chahine, Mohamed, et al.
Publicado: (2011)

Inhibition of voltage-gated Na(+) currents by eleclazine in rat atrial and ventricular myocytes
por: Caves, Rachel E., et al.
Publicado: (2020)

Agonist-specific voltage-dependent gating of lysosomal two-pore Na(+) channels
por: Zhang, Xiaoli, et al.
Publicado: (2019)

Effects of Sesamin, the Major Furofuran Lignan of Sesame Oil, on the Amplitude and Gating of Voltage-Gated Na(+) and K(+) Currents
por: Kuo, Ping-Chung, et al.
Publicado: (2020)

Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA
por: Finol-Urdaneta, Rocio K., et al.
Publicado: (2019)

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor
por: Adachi, Kanna, et al.
Publicado: (2019)

Voltage-gated Na Channel Selectivity: The Role of the Conserved Domain III Lysine Residue
por: Lipkind, Gregory M., et al.
Publicado: (2008)

Gating of Na channels in the rat cortical collecting tubule: effects of voltage and membrane stretch
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_m8gbm97hefnui90299ju2lq8a9