Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site

Chromosome segregation begins when the cysteine protease, separase, cleaves the Scc1 subunit of cohesin at the metaphase-to-anaphase transition. Separase is inhibited prior to metaphase by the tightly bound securin protein, which contains a pseudosubstrate motif that blocks the separase active site....

Descripción completa

Detalles Bibliográficos
Autores principales: Rosen, Laura E., Klebba, Joseph E., Asfaha, Jonathan B., Ghent, Chloe M., Campbell, Melody G., Cheng, Yifan, Morgan, David O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858450/
https://www.ncbi.nlm.nih.gov/pubmed/31729382
http://dx.doi.org/10.1038/s41467-019-13209-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858450/
https://www.ncbi.nlm.nih.gov/pubmed/31729382
http://dx.doi.org/10.1038/s41467-019-13209-y

Ejemplares similares