Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-κB activation

Chemoresistance to 5-fluorouracil (5-Fu)-based chemotherapy is a leading obstacle in achieving effective treatment for colorectal cancer (CRC). Typically, NF-κB activation induced by the chemotherapeutics themselves is an important cause resulting in chemoresistance. Specifically, NF-κB activation c...

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Detalles Bibliográficos
Autores principales: Fu, Jinbo, Xu, Yiming, Yang, Yushan, Liu, Yun, Ma, Lulu, Zhang, Yiyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858464/
https://www.ncbi.nlm.nih.gov/pubmed/31729451
http://dx.doi.org/10.1038/s41598-019-53276-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858464/
https://www.ncbi.nlm.nih.gov/pubmed/31729451
http://dx.doi.org/10.1038/s41598-019-53276-1

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