Cargando…
Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release
Protein cleavage inside the cell membrane triggers various patho-physiological signaling pathways, but the mechanism of catalysis is poorly understood. We solved ten structures of the Escherichia coli rhomboid protease in a bicelle membrane undergoing time-resolved steps that encompass the entire pr...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858540/ https://www.ncbi.nlm.nih.gov/pubmed/31570873 http://dx.doi.org/10.1038/s41594-019-0296-9 |