PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

Protein arginine methyltransferase 5 (PRMT5) has emerged as a promising cancer drug target, and three PRMT5 inhibitors are currently in clinical trials for multiple malignancies. In this study, we investigated the role of PRMT5 in human acute myeloid leukemia (AML). Using an enzymatic dead version o...

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Detalles Bibliográficos
Autores principales: Radzisheuskaya, Aliaksandra, Shliaha, Pavel V, Grinev, Vasily, Lorenzini, Eugenia, Kovalchuk, Sergey, Shlyueva, Daria, Gorshkov, Vladimir, Hendrickson, Ronald C, Jensen, Ole N, Helin, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858565/
https://www.ncbi.nlm.nih.gov/pubmed/31611688
http://dx.doi.org/10.1038/s41594-019-0313-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858565/
https://www.ncbi.nlm.nih.gov/pubmed/31611688
http://dx.doi.org/10.1038/s41594-019-0313-z

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