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Engineering orthogonal signaling pathways reveals the sparse occupancy of sequence space
Gene duplication is a common and powerful mechanism by which cells create new signaling pathways(1,2), but recently duplicated proteins typically must become insulated from each other, and from other paralogs, to prevent unwanted cross-talk(3). A similar challenge arises when new sensors or syntheti...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858568/ https://www.ncbi.nlm.nih.gov/pubmed/31645757 http://dx.doi.org/10.1038/s41586-019-1639-8 |