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RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors
T cell specification and commitment requires Notch signaling. Although the requirement for Notch signaling during intrathymic T cell development is known, it is still unclear whether the onset of T cell priming can occur in a pre-thymic niche and whether RBPJ-dependent Notch signaling has a role dur...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858571/ https://www.ncbi.nlm.nih.gov/pubmed/31636466 http://dx.doi.org/10.1038/s41590-019-0518-7 |