Cargando…
Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2)
BACKGROUND: Neurofibromatosis 1 and 2, although involving two different tumour suppressor genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes that disproportionately affect cells of neural crest origin. New therapeutic approaches for both NF1 and NF2 are badly ne...
Autores principales: | Shen, Yu-chi, Arellano-Garcia, Caroline, Menjivar, Rosa E., Jewett, Ethan M., Dohle, Wolfgang, Karchugina, Sofiia, Chernoff, Jonathan, Potter, Barry V. L., Barald, Kate F. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858664/ https://www.ncbi.nlm.nih.gov/pubmed/31730023 http://dx.doi.org/10.1186/s40360-019-0369-8 |
Ejemplares similares
-
Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol
por: Shen, Yu-chi, et al.
Publicado: (2015) -
Tetrahydroisoquinoline Sulfamates as Potent Microtubule
Disruptors: Synthesis, Antiproliferative and Antitubulin Activity
of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure
por: Dohle, Wolfgang, et al.
Publicado: (2019) -
2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca(2+) entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis
por: Hosang, Leon, et al.
Publicado: (2023) -
Cell Fate following Irradiation of MDA-MB-231 and MCF-7 Breast Cancer Cells Pre-Exposed to the Tetrahydroisoquinoline Sulfamate Microtubule Disruptor STX3451
por: Hargrave, Scott D., et al.
Publicado: (2022) -
2-Methoxyestradiol-3,17-O,O-bis-sulfamate (STX140) Inhibits Proliferation and Invasion via Senescence Pathway Induction in Human BRAFi-Resistant Melanoma Cells
por: Franco, Ylana Adami, et al.
Publicado: (2023)