UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor

BiP is a major ER chaperone and suggested to act as primary sensor in the activation of the unfolded protein response (UPR). How BiP operates as a molecular chaperone and as an ER stress sensor is unknown. Here, by reconstituting components of human UPR, ER stress and BiP chaperone systems, we disco...

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Detalles Bibliográficos
Autores principales: Kopp, Megan C, Larburu, Natacha, Durairaj, Vinoth, Adams, Christopher J, Ali, Maruf MU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858872/
https://www.ncbi.nlm.nih.gov/pubmed/31695187
http://dx.doi.org/10.1038/s41594-019-0324-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858872/
https://www.ncbi.nlm.nih.gov/pubmed/31695187
http://dx.doi.org/10.1038/s41594-019-0324-9

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