The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

Premature termination codons (PTCs) can result in the production of truncated proteins or the degradation of mRNAs by nonsense-mediated mRNA decay (NMD). Which of these outcomes occurs can alter the effect of a mutation, with the engagement of NMD depending upon a series of rules. Here, by applying...

Descripción completa

Detalles Bibliográficos
Autores principales: Lindeboom, Rik G.H., Vermeulen, Michiel, Lehner, Ben, Supek, Fran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858879/
https://www.ncbi.nlm.nih.gov/pubmed/31659324
http://dx.doi.org/10.1038/s41588-019-0517-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858879/
https://www.ncbi.nlm.nih.gov/pubmed/31659324
http://dx.doi.org/10.1038/s41588-019-0517-5

Ejemplares similares