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The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Premature termination codons (PTCs) can result in the production of truncated proteins or the degradation of mRNAs by nonsense-mediated mRNA decay (NMD). Which of these outcomes occurs can alter the effect of a mutation, with the engagement of NMD depending upon a series of rules. Here, by applying...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858879/ https://www.ncbi.nlm.nih.gov/pubmed/31659324 http://dx.doi.org/10.1038/s41588-019-0517-5 |