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Site-selective (1)H/(2)H labeling enables artifact-free (1)H CPMG relaxation dispersion experiments in aromatic side chains

Aromatic side chains are often key residues in enzyme active sites and protein binding sites, making them attractive probes of protein dynamics on the millisecond timescale. Such dynamic processes can be studied by aromatic (13)C or (1)H CPMG relaxation dispersion experiments. Aromatic (1)H CPMG rel...

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Detalles Bibliográficos
Autores principales: Raum, Heiner N., Schörghuber, Julia, Dreydoppel, Matthias, Lichtenecker, Roman J., Weininger, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859156/
https://www.ncbi.nlm.nih.gov/pubmed/31506857
http://dx.doi.org/10.1007/s10858-019-00275-z