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Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo

The most widely used antimalarial drugs belong to the quinoline family. Their mode of action has not been characterized at the molecular level in vivo. We report the in vivo mode of action of a bromo analog of the drug chloroquine in rapidly frozen Plasmodium falciparum-infected red blood cells. The...

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Detalles Bibliográficos
Autores principales: Kapishnikov, Sergey, Staalsø, Trine, Yang, Yang, Lee, Jiwoong, Pérez-Berná, Ana J., Pereiro, Eva, Werner, Stephan, Guttmann, Peter, Leiserowitz, Leslie, Als-Nielsen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859308/
https://www.ncbi.nlm.nih.gov/pubmed/31659055
http://dx.doi.org/10.1073/pnas.1910123116