Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

Immune-mediated diseases (IMDs) arise when tolerance is lost and chronic inflammation is targeted towards healthy tissues. Despite their growing prevalence, therapies to treat IMDs are lacking. Cytokines and their receptors orchestrate inflammatory responses by regulating elaborate signalling networ...

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Detalles Bibliográficos
Autores principales: McGowan, Lucy M, Davey Smith, George, Gaunt, Tom R, Richardson, Tom G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859431/
https://www.ncbi.nlm.nih.gov/pubmed/31276585
http://dx.doi.org/10.1093/hmg/ddz155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859431/
https://www.ncbi.nlm.nih.gov/pubmed/31276585
http://dx.doi.org/10.1093/hmg/ddz155

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