Decision-Making in Cascade Complexes Harboring crRNAs of Altered Length

The multi-subunit type I CRISPR-Cas surveillance complex Cascade uses its crRNA to recognize dsDNA targets. Recognition involves DNA unwinding and base-pairing between the crRNA spacer region and a complementary DNA strand, resulting in formation of an R-loop structure. The modular Cascade architect...

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Detalles Bibliográficos
Autores principales: Songailiene, Inga, Rutkauskas, Marius, Sinkunas, Tomas, Manakova, Elena, Wittig, Sabine, Schmidt, Carla, Siksnys, Virginijus, Seidel, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859484/
https://www.ncbi.nlm.nih.gov/pubmed/31533038
http://dx.doi.org/10.1016/j.celrep.2019.08.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859484/
https://www.ncbi.nlm.nih.gov/pubmed/31533038
http://dx.doi.org/10.1016/j.celrep.2019.08.033

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