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Decision-Making in Cascade Complexes Harboring crRNAs of Altered Length

The multi-subunit type I CRISPR-Cas surveillance complex Cascade uses its crRNA to recognize dsDNA targets. Recognition involves DNA unwinding and base-pairing between the crRNA spacer region and a complementary DNA strand, resulting in formation of an R-loop structure. The modular Cascade architect...

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Detalles Bibliográficos
Autores principales:	Songailiene, Inga, Rutkauskas, Marius, Sinkunas, Tomas, Manakova, Elena, Wittig, Sabine, Schmidt, Carla, Siksnys, Virginijus, Seidel, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859484/ https://www.ncbi.nlm.nih.gov/pubmed/31533038 http://dx.doi.org/10.1016/j.celrep.2019.08.033

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