2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct

α,β-Unsaturated aldehydes generated during lipid peroxidation, such as 2-alkenals, give rise to protein degeneration in a variety of pathological states. 2-Alkenals are highly reactive toward nucleophilic amino acid residues, such as histidine and lysine, to form Schiff base adducts or Michael addit...

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Detalles Bibliográficos
Autores principales: Yoshitake, Jun, Shibata, Takahiro, Shimayama, Chihiro, Uchida, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Structure-function relationships of protein lipoxidation and mechanisms of action
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859543/
https://www.ncbi.nlm.nih.gov/pubmed/30819615
http://dx.doi.org/10.1016/j.redox.2019.101115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859543/
https://www.ncbi.nlm.nih.gov/pubmed/30819615
http://dx.doi.org/10.1016/j.redox.2019.101115

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