Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion

In sickle cell disease (SCD), recurrent painful vasoocclusive crisis are likely caused by repeated episodes of hypoxia and reoxygenation. The sickle erythrocyte (SSRBC) adhesion plays an active role in vasoocclusion. However, the effect of prolonged reoxygenation after hypoxic stress on the molecula...

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Detalles Bibliográficos
Autores principales: MacKinney, Anson, Woska, Emily, Spasojevic, Ivan, Batinic-Haberle, Ines, Zennadi, Rahima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859575/
https://www.ncbi.nlm.nih.gov/pubmed/30661992
http://dx.doi.org/10.1016/j.redox.2019.101097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859575/
https://www.ncbi.nlm.nih.gov/pubmed/30661992
http://dx.doi.org/10.1016/j.redox.2019.101097

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