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Preferential interaction of MHC class I with TAPBPR in the absence of glycosylation

We recently discovered that TAPBPR promotes reglucosylation of the N-linked glycan on MHC class I molecules, a modification that restores their recognition by calreticulin and reincorporation into the peptide-loading complex. We wondered whether TAPBPR displayed some degree of glycan specificity, as...

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Detalles Bibliográficos
Autores principales: Neerincx, Andreas, Boyle, Louise H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859791/
https://www.ncbi.nlm.nih.gov/pubmed/30077416
http://dx.doi.org/10.1016/j.molimm.2018.06.269