HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction

The primary oncogenic event in ∼85% of Ewing sarcomas is a chromosomal translocation that generates a fusion oncogene encoding an aberrant transcription factor. The exact genomic breakpoints within the translocated genes, EWSR1 and FLI1, vary; however, in EWSR1, breakpoints typically occur within in...

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Detalles Bibliográficos
Autores principales: Neckles, Carla, Boer, Robert E., Aboreden, Nicholas, Cross, Allison M., Walker, Robert L., Kim, Bong-Hyun, Kim, Suntae, Schneekloth, John S., Caplen, Natasha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859848/
https://www.ncbi.nlm.nih.gov/pubmed/31511320
http://dx.doi.org/10.1261/rna.072454.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859848/
https://www.ncbi.nlm.nih.gov/pubmed/31511320
http://dx.doi.org/10.1261/rna.072454.119

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