Coding regions affect mRNA stability in human cells

A new paradigm has emerged that coding regions can regulate mRNA stability in model organisms. Here, due to differences in cognate tRNA abundance, synonymous codons are translated at different speeds, and slow codons then stimulate mRNA decay. To ask if this phenomenon also occurs in humans, we isol...

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Detalles Bibliográficos
Autores principales: Narula, Ashrut, Ellis, James, Taliaferro, J. Matthew, Rissland, Olivia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859850/
https://www.ncbi.nlm.nih.gov/pubmed/31527111
http://dx.doi.org/10.1261/rna.073239.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859850/
https://www.ncbi.nlm.nih.gov/pubmed/31527111
http://dx.doi.org/10.1261/rna.073239.119

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