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Interplay between substrate recognition, 5′ end tRNA processing and methylation activity of human mitochondrial RNase P

Human mitochondrial ribonuclease P (mtRNase P) is an essential three-protein complex that catalyzes the 5′ end maturation of mitochondrial precursor tRNAs (pre-tRNAs). Mitochondrial RNase P Protein 3 (MRPP3), a protein-only RNase P (PRORP), is the nuclease component of the mtRNase P complex and requ...

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Detalles Bibliográficos
Autores principales: Karasik, Agnes, Fierke, Carol A., Koutmos, Markos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859853/
https://www.ncbi.nlm.nih.gov/pubmed/31455609
http://dx.doi.org/10.1261/rna.069310.118